- Chris Davis, Nicola Logan, Grace Tyson, Richard Orton, William T. Harvey, Jonathan S. Perkins, Guy Mollett, Rachel M. Blacow, Thomas P. Peacock, Wendy S. Barclay, Peter Cherepanov, Massimo Palmarini, Pablo R. Murcia, Arvind H. Patel, David L. Robertson, John Haughney, Emma C. Thomson, Brian J. Willett. Reduced neutralisation of the Delta (B.1.617.2) SARS-CoV-2 variant of concern following vaccination. PLOS Pathogens, 2021; 17 (12): e1010022 DOI: 10.1371/journal.ppat.1010022
Mutations change the shape of the COVID-19 spike protein, preventing antibody recognition and enabling the virus to escape vaccine-induced immunity; however, the extent to which vaccine recipients are immune from the Delta variant is unknown. To quantify the capacity of different variants (Alpha, Beta and Delta) to evade protective immune response in vaccines, researchers analyzed serum samples collected from healthy people who had received either the Pfizer or Astra Zeneca vaccine. 156 people had received two doses and 50 people had received one dose. They exposed SARS-CoV-2 proteins in a virus model system to sera from vaccinated people and observed the antibody response, measuring how effectively antibodies prevented each variant from infecting cells (virus neutralization).
The researchers found that vaccines conferred protection from all COVID-19 variants but noted reduced antibody neutralization of both the Beta and Delta variants. Across all vaccinated individuals, the Delta variant reduced the immune response in recipients of both the Pfizer and Astra Zeneca vaccine 4.31 and 5.11-fold respectively. The study was not designed to measure vaccine efficacy directly, although it was in keeping with recent findings from Public Health England of slightly lower vaccine effectiveness against the Delta variant than previous variants. It also did not report on serological study of people who received the Moderna or Johnson & Johnson vaccines.
According to the authors, “While vaccines remain highly effective at preventing severe infection and death, ongoing monitoring of neutralization against new variants alongside studies of vaccine effectiveness are indicated as the virus continues to evolve over time, especially in vulnerable groups. Booster vaccines reduce the chance of being infected with currently circulating new variants. Newer updated vaccine designs are also likely to be required in time to prevent productive infection with newer variants of the virus.”